The multiple crises of recent years have shown that the current development model is unsustainable and fails to address the structural gaps that affect the vast majority of the population of Latin America and the Caribbean. Against this backdrop, a comprehensive and cross-cutting approach is needed to halt the enormous setbacks that jeopardize achievements of the targets set in the 2030 Agenda for Sustainable Development and the Regional Gender Agenda. It is also urgent to implement the structural change in the development model that ECLAC has been advocating for over a decade.